Innovative Medical Technology

Neurotron, Incorporated

   Innovative Medical Technology

                 Established 1981

Neurometer® CPT/LAB Laboratory Animal Testing

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Laboratory animal testing is performed using the Neurometer CPT/LAB device which permits atraumatic, non-injurious and non-invasive neuroselective sensory evaluations.  The utility of this evaluation has been substantiated by numerous scientific publications.  A computer program operates the Neurometer CPT/C device.  The device may be manually operated or controlled by an optional laptop/netbook monitoring system or optional printer.  The computer permits customization of stimulus parameters and the creation of animal/site specific testing "profiles", data storage, audio calibration, and trigger controls to permit vocalization and other response thresholds to be automated. Ideal for laboratory animal testing, especially repeated testing over hours or years.  The Neurometer evaluation provides quantitative reproducible results for laboratory animal testing. The electrophysiological measure is superior to the tail flick and other response threshold tests for the following reasons:

(dot) Atraumatic/Non-Injurious- does not hurt lab animals
(dot) Easily performed at any cutaneous mucosal site (including bladder studies).
(dot) Reproducible- Neurometer results have been proven to be reproducible in studies performed at 10 minute intervals or over multiple days with lifetime studies from the NIH as long as 103 weeks. The NIH researchers concluded the Neurometer vocalization studies were non-injurious, lack the habituation reported with thermal and mechanical stimuli and contributes to the armamentarium of tools to study nociception.
(dot) Quantifiable- Neurometer results are measured with a numerical score at each nerve sub-population which can be compared to like scores of other animals and over time with the same animal.
(dot) Neuroselective- Neurometer independently evaluates A-Beta, A-Delta, and C-Fibers of sensory nerves. Each sub population of nerves provides unique research information that is lost with generic pain testing.

Laboratory animal testing is performed using a small testing electrode in combination with a dispersion electrode which may be cut down to a custom size.  For example the mouse below is in a restraining tube, with a microphone in front of the tube and a stimulating and dispersion electrode placed on the tail.

       Restraining Tube                      Top View                             Side View

(dot) Video of electrode application
(dot) Video of vocalization threshold testing session (it may be be necessary to increase your volume setting to hear the vocalization)



Lifetime Study Reference: Finkle, J., Besch, V., Hergen, A., Kakareka, J., Pohida, T., Melzer, J., Koziol, D., Wesley, R., Quezado, Z. Effects of Aging on Current Vocalization Threshold in Mice Measured by a Novel Nociception Assay. Anesthesiology. Vol. 105;360-9, 2006. National Institutes of Health, USA.

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rev 04/222/11